2-Butoxyethanol is not currently used in a proprietary ingredient (PI formulation). For example, laboratory animals treated with EGME were observed to develop testicular atrophy, bone marrow hypoplasia (pancytopenia) with secondary effects on red blood cell and white blood cell indices. There are also reports that EGEE and EGBE cause kidney enlargement without functional impairment. Propylene glycol is used as a solvent in commercial products as well as a diluent for oral, topical, and intravenous pharmaceutical preparations. The PSC also noted that other alkyl ethers of demonstrated haematological effects which increased with chain lengths. Acetaminophen, antibiotics (e.g., amphotericin B, bacitracin, gentamycin, neomycin, oxytetracycline, paromomycin, polymixin-B, sulfonamides), Aristolochia (birthwort), bismuth, boric acid, 2-butoxyethanol, cadmium, calcipotriene or calcipotriol, cantharidin, carbamate fungicides, carbon tetrachloride, cholecalciferol, chromium, citrinin, copper, diethylene glycol, diquat, ethylene glycol, grapes, lead, lilies (Hemerocallis, Lilium), mercury, mothballs, mushrooms, nonsteroidal antiinflammatory agents, ochratoxin, oxalic acid (e.g., Oxalis, Rheum, Rumex), paraquat, petroleum hydrocarbons (e.g., diesel fuel, gasoline, kerosene), phenol, raisins, toluene, uranium, vitamin D–containing plants (e.g., Cestrum diurnum, Solanum malacoxylon), zinc. SAFETY DATA SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 4 1. Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. GUNNAR F. NORDBERG, ... BRUCE A. FOWLER, in Handbook on the Toxicology of Metals (Third Edition), 2007. Thus, the dietary iron enrichment may enhance the incidence and severity of estrogen-induced tumor induction (Wyllie and Liehr, 1998). Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. In November 2013, based on the ACCS advice, the delegate created a separate schedule entry for hexyloxyethanol with a cut-off level to exempt from scheduling for preparations containing 10 per cent of less of hexyloxyethanol. 2-Butoxyethanol appears in the Appendix A to section 1926.55-1970 American Conference of Governmental Industrial Hygienist's threshold limit values of airborne contaminants of the Electronic Code of Federal Regulations as follows: Butoxyethanol in is Annex III to Regulation (EC) No 1223/2009 and is permitted for use as a solvent in oxidative hair dye products at 4% and in non-oxidative hair dye products at 2%. The level of exposure depends upon the dose, duration, and work being done. It is a well-known fact that both the parent compound and its metabolites may mediate toxicity. u 2-butoxyethanol (or ethylene glycol monobutyl ether) and other glycol ethers u Alkylphenol ethoxylates (some common ones are: nonylphenol and octylphenol ethoxylates, or octoxynols) u Bisphenol A bu d-Limonene u Dyes (may be listed as FD&C or D&C) u Ethanolamines (common ones to look out for are: monoethanolamine [MEA], The iron chelator phenanthroline suppressed the sodium chloride–enhanced gastric car-cinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in experiments on Wistar rats (Tatsuta et al., 2003). Property Name Property Value Reference; Molecular Weight: 162.23 g/mol: Computed by PubChem 2.1 (PubChem release 2019.06.18) XLogP3-AA: 1: Computed by XLogP3 3.0 (PubChem release 2019.06.18) Butoxyethanol is not permitted for use in aerosol dispenser (sprays). Joint Advisory Committee on Medicines and Chemicals Scheduling (Joint ACMS-ACCS #19), On this page: Delegate's interim decision | Delegate's considerations | Scheduling proposal | Background information for 2-butoxyethanol. Hazardous materials are non-returnable. It is prepared by reacting 2-butoxyethanol with acetic acid, acetic acid anhydride, or acetic acid chloride. DOES NOT CONTAIN HARMFUL INGREDIENTS such as Ammonia, Sodium Hydroxide, 2-Butoxyethanol, Methanol or Perchloroethylene. Additional toxicities include neurotoxicity (loss of coordination, sluggishness and narcosis) and nephrotoxicity. Based on these case reports and overall theoretical considerations, it would be reasonable to treat these poisonings like those with ethylene glycol poisoning. Chlorine Dioxide (CLO2) “The Ideal Disinfectant” is highly effective against Viruses, Bacteria, Mold, Fungi, Algae, Protozoa, and Biofilm. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Since it is significantly less toxic as compared to ethylene glycol, propylene glycol is the preferred antifreeze used in motor homes and recreational vehicles. In addition, there is considerable variation in the susceptibility of cells from different mouse strains to the nitroso metabolite. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. Acetic acid or white vinegar is a great disinfectant. The authors suggest that iron may also act as a promoter of already initiated hepatocytes in the development of liver cancer in humans (Carthew et al., 1997). Coma and hypotension were present upon admission and later metabolic acidosis gradually developed. Despite evidence in the NICNAS IMAP report which suggested that concentrations higher than 10 per cent can be used safely for some alkoxyethanols, the ACCS did not recommend raising the current 10 per cent cut-off. In another case without ethanol, metabolic acidosis was accompanied with coma, hypokalemia, hemoglobinuria, oxaluria and a transitory rise in the serum creatinine level [74]. EGME was teratogenic, embryotoxic, and fetotoxic in pregnant animals. The formulated product had low toxicity via the oral, dermal and inhalation routes of exposure as follows: The primary eye irritation study with the formulated product revealed slight irritation that resolved completely by 48 hours following administration of the test material. We use cookies to help provide and enhance our service and tailor content and ads. This group consists of the monoalkyl ethers of ethylene glycol (EG), including EG butyl ether (butylglycol, butyl Cellosolve), EG monomethyl ether (methyl Cellosolve) and EG monoethyl ether (Cellosolve). In rats, adverse effects on the central nervous system, kidneys, and liver occur at higher exposure concentrations than do haemolytic effects. In humans, increased body stores of iron have been shown to increase the risk of several estrogen-induced cancers (e.g., breast cancer; Liehr and Jones [2001]). The other patient had no evidence of renal disorder or oxalate crystals in the urine. 2-Butoxyethanol acetate is widely used as a slow-evaporating solvent for lacquers, varnishes, epoxy resins, and enamels. 111-76-2. Table 22.2. This bathroom cleaner contains up to 10 percent of a toxic solvent called 2-butoxyethanol. Continue flushing until advised to stop by a Poisons Information Centre (e.g. 2-Butoxyethanol is used as a solvent in a range of applications. Immune studies involving glycol ethers are limited when compared with other major categories (e.g., heavy metals and dioxins) of EDCs. However, exposure to compounds in the propylene series was not lethal to rodents even at nearly saturated concentrations. However, the Draize scores indicate that at those concentrations, it is practically non-irritating (scores of 1/110 and 2/110 at 10% and 20%, respectively) (Kennah et al., 1989). 2010. To keep glass germ-free, use a disinfectant first and then wipe it down with Windex Original Glass Cleaner. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. But there are some Windex products that do kill germs, like Windex Disinfectant Multi-Surface Cleaner. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex … 2-Butoxyethanol has haemolytic and Central Nervous System (CNS) effects, low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. The Schedule 6 entry for ethylene glycol monoalkyl ethers and their acetates was also amended at this time to add the exception 'when separately specified in these Schedules'. 2-Butoxyethanol is not considered to be genotoxic. D. Jacobsen, K.E. Restrictions apply to its use in listed medicines according to the Therapeutic Goods (Permissible Ingredients) Determination No.2 of 2018: Purpose of the ingredient in the medicine, Specific requirement(s) applying to the ingredient in Column 2. A member of the “glycol ethers” group, 2-butoxyethanol is a primary ingredient in many all-purpose cleaners. Oxidative DNA damage increased in Syrian Hamster Embryo cells after treatment with ferrous sulfate. Butoxyethanol is an excipient ingredient in 5 products on the Australian Register of Therapeutic Goods (ARTG). One such compound that has been extensively tested is microcystin-LR, which significantly increases oxidative stress causing lipid peroxidation, changes in membrane fluidity, transformations of cell shape and hemolysis. The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. Iron may act as a promoter of dimethylnitrosamineinitiated hepatocytes in rats. Glycols are associated with severe morbidity and an increased risk of death. In August 1998, the NDPSC noted that 2-butoxyethanol is currently included in Schedule 6 (in preparations containing > 10%) through the class entry of ethylene glycol monoalkyl and their acetates. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. Skin and eye irritation consistent with Schedule 6. Experiments on hamsters have shown that estrogen treatment increased the non-heme iron in liver of both high and low iron treatment groups and in kidney of the hamsters on the low-iron diet. EPA conducted independent studies to determine the hazards of the dispersants including COREXIT 9500A, and the cytotoxicity results in vitro in concentrations above 10 ppm showed that none of the eight dispersants tested displayed significant estrogenic and androgenic activity. Alys Bradley, ... Adam Hargreaves, in Boorman's Pathology of the Rat (Second Edition), 2018. Lysol Disinfectant Max Cover Mist Purell Professional Surface Disinfectant Wipes The EPA also included the time a surface should remain wet with … Continued treatment with 2-butoxyethanol resulted in hemosiderin deposition in the liver, indicating that the liver tumors were mediated by oxidative iron catalyzed stress and Kupffer cell activation (Park et al., 2002). The product used in butyl degreaser--2-butoxyethanol--has an ether scent and is colorless. And dioctyl Sodium sulfosuccinate glycol Monobutyl Ether ( EGBE ) ( CAS No Multi-Surface Cleaner the urine are reports... Pharmaceutical preparations central nervous system, kidneys, and enamels varnishes, epoxy resins and., exposure to compounds in the urine kidney enlargement without functional impairment Hargreaves, in Boorman 's of... Of EDCs the dose, duration, and liver occur at higher exposure concentrations do... Exposure depends upon the dose, duration, and work being done propylene! 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